A comprehensive genetic screen for recessive mutations impairing fertility and rearing success of Swiss cattle

Single recessive mutations can determine both insemination success and the vitality of newborns, thereby affecting fertility and rearing success.

Steckbrief

  • Departement BFH | Hochschule für Agrar-, Forst- und Lebensmittelwissenschaften
  • Forschungsschwerpunkt Ressourceneffiziente landwirtschaftliche Produktionssysteme
  • Forschungsfeld Nutztiersysteme und Pferdehaltung
  • Förderorganisation SNF
  • Laufzeit (geplant) 01.09.2017 - 31.08.2021
  • Projektverantwortung Heidi Signer-Hasler
  • Projektleitung Heidi Signer-Hasler
  • Projektmitarbeitende Heidi Signer-Hasler
    Christine Flury
  • Mitwirkende Projektpartner Wirtschaft Qualitas
  • Mitwirkende Projektpartner Forschungsinstitutionen inkl. BFH Universität Bern Bioinformatics
    Universität Bern Vetsuisse
  • Mitwirkende Projektpartner öffentliche Hand SNF
  • Schlüsselwörter cattle, fertility, mutation, animal breeding, animal health, next generation sequencing

Ausgangslage

Whole genome sequencing for the identification of recessive mutations affecting fertility and rearing success based on homozygous haplotype deficiency scans. A reverse genetics approach for identification of other disruptive mutations in the absence of affected animals in Swiss cattle by mining Whole genome sequencing. Validation and characterization of candidate mutations to identify true causative mutations impairing reproduction.

Ziel

The project aims at a better understanding of the genetic mechanisms in cattle that influence reproduction and viability characteristics in cattle.

Kernkompetenzen

analysis of whole genome sequences and large-scale SNP genotype data