SNF - Rezessive Mutationen Rind

Single recessive mutations can determine both insemination success and the vitality of newborns, thereby affecting fertility and rearing success.

Steckbrief

  • Lead-Departement Hochschule für Agrar-, Forst- und Lebensmittelwissenschaften
  • Institut Ressourceneffiziente landwirtschaftliche Produktionssysteme
  • Forschungseinheit Nutztiersysteme und Pferdehaltung
  • Förderorganisation SNF
  • Laufzeit (geplant) 01.09.2017 - 31.08.2021
  • Projektverantwortung Heidi Signer-Hasler
  • Projektleitung Heidi Signer-Hasler
  • Projektmitarbeitende Christine Flury
    Heidi Signer-Hasler
  • Partner Qualitas AG
    Universität Bern Vetsuisse
    Universität Bern Bioinformatics
    SNF
  • Schlüsselwörter cattle, fertility, mutation, animal breeding, animal health, next generation sequencing

Ausgangslage

The project aims at a better understanding of the genetic mechanisms in cattle that influence reproduction and viability characteristics in cattle.

Vorgehen

Whole genome sequencing for the identification of recessive mutations affecting fertility and rearing success based on homozygous haplotype deficiency scans. A reverse genetics approach for identification of other disruptive mutations in the absence of affected animals in Swiss cattle by mining Whole genome sequencing. Validation and characterization of candidate mutations to identify true causative mutations impairing reproduction.