A comprehensive genetic screen for recessive mutations
Single recessive mutations can determine both insemination success and the vitality of newborns, thereby affecting fertility and rearing success.
Steckbrief
- Lead-Departement Hochschule für Agrar-, Forst- und Lebensmittelwissenschaften
- Institut Agronomie
- Forschungseinheit Nutztiere und Pferde
- Förderorganisation SNF
- Laufzeit 01.09.2017 - 31.05.2022
- Projektverantwortung Dr. Heidi Signer-Hasler
- Projektleitung Dr. Heidi Signer-Hasler
-
Projektmitarbeitende
Christine Flury
Dr. Heidi Signer-Hasler -
Partner
Qualitas AG
Universität Bern Vetsuisse
Universität Bern Bioinformatics
Schweizerischer Nationalfonds SNF - Schlüsselwörter cattle, fertility, mutation, animal breeding, animal health, next generation sequencing
Ausgangslage
The project aims at a better understanding of the genetic mechanisms in cattle that influence reproduction and viability characteristics in cattle.
Vorgehen
Whole genome sequencing for the identification of recessive mutations affecting fertility and rearing success based on homozygous haplotype deficiency scans. A reverse genetics approach for identification of other disruptive mutations in the absence of affected animals in Swiss cattle by mining Whole genome sequencing. Validation and characterization of candidate mutations to identify true causative mutations impairing reproduction.
