A comprehensive genetic screen for recessive mutations
Single recessive mutations can determine both insemination success and the vitality of newborns, thereby affecting fertility and rearing success.
- Lead school School of Agricultural, Forest and Food Sciences
- Institute Agriculture
- Research unit Livestock and Horses
- Funding organisation SNSF
- Duration 01.09.2017 - 31.05.2022
- Project management Dr. Heidi Signer-Hasler
- Head of project Dr. Heidi Signer-Hasler
Dr. Heidi Signer-Hasler
Universität Bern Vetsuisse
Universität Bern Bioinformatics
Schweizerischer Nationalfonds SNF
- Keywords cattle, fertility, mutation, animal breeding, animal health, next generation sequencing
The project aims at a better understanding of the genetic mechanisms in cattle that influence reproduction and viability characteristics in cattle.
Course of action
Whole genome sequencing for the identification of recessive mutations affecting fertility and rearing success based on homozygous haplotype deficiency scans. A reverse genetics approach for identification of other disruptive mutations in the absence of affected animals in Swiss cattle by mining Whole genome sequencing. Validation and characterization of candidate mutations to identify true causative mutations impairing reproduction.