Le conseil nutritionnel à l'ère des modulateurs du gène CFTR
The aim is to develop new evidence-based, collaboratively developed and practical recommendations for dietary advice for people with cystic fibrosis who are undergoing CFTR modulator therapy.
Factsheet
- Schools involved School of Health Professions
- Institute(s) Nutrition and Dietetics
- Funding organisation Others
- Duration (planned) 01.07.2024 - 31.12.2027
- Head of project Prof. Dr. Julia Eisenblätter
-
Project staff
Isabelle Fabienne Rieckh
Jessica Stalder
Karin Andrea Stalder - Partner Cystische Fibrose Schweiz
- Keywords Cystic fibrosis, CFTR modulators, nutritional therapy, nutritional counselling, participation, implementation, Delphi method, Nutrition Care Process
Situation
CFTR modulators have fundamentally changed the treatment of cystic fibrosis (CF). In addition to improved lung function, a significant impact on nutritional status has been observed, which is closely associated with morbidity and mortality. Existing dietary recommendations for people with CF were primarily developed for malnourished patients and do not adequately reflect the changing needs under CFTR modulator therapy, nor do they provide sufficient guidance for current counselling practice. Under the new therapy, emerging challenges include overweight and obesity, changing requirements in diabetes management, and the need to adjust enzyme and vitamin therapy. At the same time, many individuals with CF have been accustomed since early childhood to a high-calorie, high-fat diet, making sustainable changes in eating behaviour difficult. There is therefore a clear need for updated, evidence-based and practice-oriented recommendations for nutritional counselling of people with CF undergoing CFTR modulator therapy.
Course of action
The recommendations will be developed using a participatory approach involving people with CF, their caregivers and specialised dietitians. Methodologically, the project is guided by the AGREE II criteria and structured according to the Nutrition Care Process. Relevant PICO questions will first be defined in workshops. This will be followed by a systematic literature review to address these questions. Based on the evidence, recommendations will be formulated and agreed upon using a Delphi process. The resulting recommendations will be prepared in a target group-specific manner (scientific publication, version for healthcare professionals, and version for people with CF including supporting materials). In a subsequent implementation phase, the recommendations will be tested in four Swiss hospitals. Facilitators and barriers to implementation in clinical practice will be systematically assessed through qualitative interviews with dietitians.
Result
The project will deliver evidence-based and consensus-driven recommendations for the nutritional counselling of people with CF undergoing CFTR modulator therapy. These will be available as concrete, practice-oriented recommendations, tailored to individual needs and aligned with the current requirements of people with CF. In addition, target group-specific materials for healthcare professionals and people with CF will be developed to support implementation in everyday practice. The implementation phase will generate important insights into facilitators and barriers to applying the recommendations in clinical settings and will enable targeted optimisation of their practical applicability.
Looking ahead
The developed recommendations will provide a foundation for updated and needs-based nutritional therapy in CF under CFTR modulator therapy. Insights from the implementation phase will support the further development of strategies for the sustainable integration of the recommendations into clinical practice. In the long term, the recommendations are expected to improve nutritional care for people with CF and may contribute to the development of national and international guidelines.
